Ferguson KA, Huh CY, Amilhon B, Williams S, Skinner FK (2014) Simple, biologically-constrained CA1 pyramidal cell models using an intact, whole hippocampus context. F1000Res 3:104 Izhikevich-based models of CA1 pyramidal cells, with parameters constrained based on a whole hippocampus preparation. Strongly and weakly adapting models based on the experimental data have been developed. Code produces example model output.

ABSTRACT: A Markov model of the cardiac sodium channel is presented. The model is similar to the CA1 hippocampal neuron sodium channel model developed by Kuo and Bean (1994. Neuron. 12:819 - 829) with the following modifications: 1) an additional open state is added; 2) open-inactivated transitions are made voltage-dependent; and 3) channel rate constants are exponential functions of enthalpy, entropy, and voltage and have explicit temperature dependence. Model parameters are determined using a simulated annealing algorithm to minimize the error between model responses and various experimental data sets. The model reproduces a wide range of experimental data including ionic currents, gating currents, tail currents, steady-state inactivation, recovery from inactivation, and open time distributions over a temperature range of 10C to 25C. The model also predicts measures of single channel activity such as first latency, probability of a null sweep, and probability of reopening.