Mitochondrial Modulation of Intracellular Ca2+ Signalling
Description
In 2001 Christopher Fall and Joel Keizer published a detailed mathematical model to describe mitochondrial function and mitochondrial Ca2+ handling coupled to endoplasmic reticulum (ER) based IP3-dependent Ca2+ release. Their aim was to create a biologically realistic model of the influence of mitochondria on IP3-mediated Ca2+ signaling. They aimed to integrate the separate IP3 receptor/channel (DeYoung-Keizer 1992) and mitochondrial Ca2+ handling (Magnus-Keizer 1997, 1998) models into a single, common framework (see the figure below).
In 2001 Christopher Fall and Joel Keizer published a detailed mathematical model to describe mitochondrial function and mitochondrial Ca2+ handling coupled to endoplasmic reticulum (ER) based IP3-dependent Ca2+ release. Their aim was to create a biologically realistic model of the influence of mitochondria on IP3-mediated Ca2+ signaling. They aimed to integrate the separate IP3 receptor/channel (DeYoung-Keizer 1992) and mitochondrial Ca2+ handling (Magnus-Keizer 1997, 1998) models into a single, common framework (see the figure below).