Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic Model
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Predator-prey dynamics
Description
The Lotka–Volterra equations, also known as the predator–prey equations, are a pair of first-order, non-linear, differential equations frequently used to describe the dynamics of biological systems in which two species interact, one a predator and one its prey. They were proposed independently by Alfred J. Lotka in 1925 and Vito Volterra in 1926. This model is parameterised as follows: x = 3, y = 6, A = 1, B = 1, C = 1, D = 1.
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Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth after administration of an anti-angiogenic agent, bevacizumab, as single-agent and combination therapy in tumor xenografts.
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Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth after administration of an anti-angiogenic agent, bevacizumab, as single-agent and combination therapy in tumor xenografts. Rocchetti M, Germani M, Del Bene F, Poggesi I, Magni P, Pesenti E, De Nicolao G Cancer chemotherapy and pharmacology, 5/2013, Volume 71, Issue 5, pages: 1147-1157
The complete original paper reference is cited below:
Population-based analysis of methadone distribution and metabolism using an age-dependent physiologically based pharmacokinetic model, Feng Yang, Xianping Tong, D. Gail. McCarver, Ronald N. Hines and Daniel A. Beard, 2006, Journal of Pharmacokinetics and Pharmacodynamics , volume 33, issue 4. PubMed ID: 16758333