Modeling Formalism
Displaying: 3 Found: 8 Total: 31
Boolean Model
Description
Boolean models model networks of genes by boolean variables that represent active and inactive states. At each time step, the state of each gene is determined by a logic rule which is a function of the state of its regulators. The state of all genes forms a global state that changes synchronously.
Formats
Constraint-based Model
Description
The constraint-based modeling procedure does not strive to find a single solution but rather finds a collection of all allowable solutions to the governing equations that can be defined (a solution space). The subsequent application of additional constraints further reduces the solution space and, consequently, reduces the number of allowable solutions that a cell can utilize. Can be analysed using flux balance analysis.
Formats
Gene regulatory network
Description
Gene regulation controls the expression of genes and, consequently, all cellular functions. Gene expression is a process that involves transcription of the gene into mRNA, followed by translation to a protein, which may be subject to post-translational modification. The transcription process is controlled by transcription factors (TFs) that can work as activators or inhibitors. TFs are themselves encoded by genes and subject to regulation, which altogether forms complex regulatory networks.